Protein G Magnetic Beads are affinity-based magnetic particles designed for the selective capture, isolation, purification, and immobilization of immunoglobulins and Fc-containing proteins. The bead surface is functionalized with Protein G, an immunoglobulin-binding protein derived from *Streptococcus* species that specifically interacts with the Fc region of a broad range of mammalian IgG subclasses. Compared with Protein A, Protein G exhibits a different antibody subclass and species-binding profile and is particularly useful for the capture of IgG antibodies from species or subclasses that display weak or variable binding to Protein A. The magnetic bead format enables rapid and efficient separation of antibody-bound complexes from complex biological samples using an external magnetic field, eliminating the need for centrifugation or column-based purification. Protein G Magnetic Beads are suitable for antibody purification, immunoprecipitation (IP), co-immunoprecipitation (Co-IP), antibody enrichment, antigen–antibody capture, protein interaction studies, and other affinity-based applications. Depending on the bead formulation, particle size, surface chemistry, Protein G ligand density, antibody binding capacity, and buffer compatibility can be optimized to support sensitive analytical applications, routine laboratory workflows, and automated high-throughput sample processing.